Southern Comfort is a whiskey-based liqueur with flavors of fruit, spices, and vanilla. In the context of alcohol and cocktails, Southern Comfort adds a sweet, smooth, and slightly spiced note to drinks. It pairs well with mixers like cola, orange juice, and lemonade, and is often used in cocktails such as the Alabama Slammer, Comfort Collins, and Southern Comfort Old Fashioned. The liqueur's rich and versatile flavor profile makes it a popular choice for both classic and contemporary cocktails.